One of the possible perks to gain is called " The Professional," complete with image of a Badass Longcoat, Cool Shades, Guns Akimbo Assassin.
A domesticated mole rat in Sloan is named Snuffles.
A drug addict expresses surprise and disbelief at seeing corn in his.
One of the brains you can heal Rex with comes from a dog named Rey.
A pretty darn obscure one is the New Vegas Samurai trophy/achievement.
A criminal with a love for explosives with the last name Cobb, first initial J? Where have we heard that before?.
Upon finding all four pages of the body's diary (one on the truck, one in each farmhouse, one in the house) you will learn that his parents were turned into Feral Ghouls, he killed them, and then thought that the animals were plotting to kill him and take over the farm.
You can find a farm with two damaged farmhouses, a pickup and burnt down house with a dead body.
A sidequest in Camp Searchlight is called "We Will All Go Together".
Extra points for the game including the first song in one of the game's radio stations to hammer in the shout-out even further.
Most of the quests are named after song titles, such as "Ain't That a Kick in the Head", "My Kind of Town", "Return to Sender" and "Climb Ev'ry Mountain" (while hunting down the sniper in the hills near Bitter Springs).